Cold Preflush of Porcine Kidney Grafts Prior to Normothermic Machine Perfusion Aggravates Ischemia Reperfusion Injury
نویسندگان
چکیده
منابع مشابه
Ischemia/reperfusion during normothermic perfusion.
INTRODUCTION Cold storage of organs for preservation and transplantation is reaching its limits especially with extended criteria for heart beating donors and donation after cardiac death. We will discuss recent findings and perspectives in normothermic kidney preservation. METHODS A literature review was performed from original articles and syntheses selected by the search engine PubMed. Key...
متن کاملNormothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
Kidney transplantation has become a well-established treatment option for patients with end-stage renal failure. The persisting organ shortage remains a serious problem. Therefore, the acceptance criteria for organ donors have been extended leading to the usage of marginal kidney grafts. These marginal organs tolerate cold storage poorly resulting in increased preservation injury and higher rat...
متن کاملDoes machine perfusion decrease ischemia reperfusion injury?
In 1990's, use of machine perfusion for organ preservation has been abandoned because of improvement of preservation solutions, efficient without perfusion, easy to use and cheaper. Since the last 15 years, a renewed interest for machine perfusion emerged based on studies performed on preclinical model and seems to make consensus in case of expanded criteria donors or deceased after cardiac dea...
متن کاملAcetazolamide protects steatotic liver grafts against cold ischemia reperfusion injury.
Ischemia reperfusion injury (IRI) is a primary concern in liver transplantation, especially when steatosis is present. Acetazolamide (AZ), a specific carbonic anhydrase (CA) inhibitor, has been suggested to protect against hypoxia. Here, we hypothesized that AZ administration could be efficient to protect fatty livers against cold IRI. Obese Zucker rat livers were preserved in Institut Georges ...
متن کاملCorrection: Gradual Rewarming with Gradual Increase in Pressure during Machine Perfusion after Cold Static Preservation Reduces Kidney Ischemia Reperfusion Injury
The fourth and seventh authors’ names are spelled incorrectly. The correct names are: Nils ‘t Hart and Paulo N Martins. The correct citation is: Mahboub P, Ottens P, Seelen M, ‘t Hart N, Van Goor H, Ploeg R, et al. (2015) Gradual Rewarming with Gradual Increase in Pressure during Machine Perfusion after Cold Static Preservation Reduces Kidney Ischemia Reperfusion Injury. PLoS ONE 10(12): e01438...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-50101-7